Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease, with hitherto unknown origin. It ranges from a mild disease course, to progressive hepatitis with fatal outcome.
Antibodies against the asialoglycoprotein receptor (ASGPR) are described in approximately 80 % of all patients with active AIH of types I or II. In contrast to other liver specific autoantibodies, antibodies against ASGPR are a marker of histological activity of liver disease. During therapy with corticosteroids, anti-ASGPR can be used for therapeutic monitoring.
- The only commercially available ELISA with highly purified ASGPR from rabbit liver
- Anti-ASGPR is the only organ specific autoantibody in autoimmune liver disease
- Anti-ASGPR allows the serological follow-up of AIH
- Anti-ASGPR allows a differential diagnosis, to rule out toxic and other inflammatory liver diseases.